Pharmacokinetics And Metabolism In Drug Design

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Pharmacokinetics And Metabolism In Drug Design

Pharmacokinetics And Metabolism In Drug Design
Author: Dennis A. Smith
Publisher: John Wiley & Sons
ISBN: 3527329544
Size: 62.39 MB
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In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug Discovery scientist. The authors discuss the parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects. Uniquely comprehensive, the book relates physicochemistry and chemical structure to pharmacokinetic properties and ultimately drug efficacy and safety.
Pharmacokinetics and Metabolism in Drug Design
Language: en
Pages: 268
Authors: Dennis A. Smith, Charlotte Allerton, Amit S. Kalgutkar, Han van de Waterbeemd, Don K. Walker
Categories: Medical
Type: BOOK - Published: 2012-05-14 - Publisher: John Wiley & Sons
In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug Discovery scientist. The authors discuss the parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects. Uniquely comprehensive, the book relates physicochemistry and chemical structure to pharmacokinetic properties and ultimately drug efficacy and safety.
A Handbook of Bioanalysis and Drug Metabolism
Language: en
Pages: 408
Authors: Gary Evans
Categories: Medical
Type: BOOK - Published: 2004-03-29 - Publisher: CRC Press
Recent years have seen a greater industrial emphasis in undergraduate and postgraduate courses in the pharmaceutical and chemical sciences. However, textbooks have been slow to adapt, leaving the field without a text/reference that is both instructional and practical in the industrial setting – until now. A Handbook of Bioanalysis and Drug Metabolismis a stimulating new text that examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. These three areas of research help drug developers to optimize the active component within potential drugs thereby increasing their effectiveness, and to provide safety and efficacy information required by regulators when granting a drug license. Professionals with extensive experience in drug discovery and development as well as specialized knowledge of the individual topics contributed to each chapter to create a current and well-credentialed text. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics and drug–drug interactions. The unique industrial perspective helps to reinforce theory and develop valuable analytical and interpreting skills. This text is an invaluable guide to students in courses such as pharmaceutical science, pharmacology, chemistry, physiology and toxicology, as well as professionals in
Pharmacokinetics in Drug Development
Language: en
Pages: 319
Authors: Peter L. Bonate, Danny R. Howard
Categories: Medical
Type: BOOK - Published: 2011-02-21 - Publisher: Springer Science & Business Media
The topics chosen for this volume were selected because they are some of the current development or technological issues facing drug development project teams. They regard the practical considerations for assessment of selected special development populations. For example, they include characterization of drug disposition in pregnant subjects, for measuring arrhythmic potential, for analysis tumor growth modeling, and for disease progression modeling. Practical considerations for metabolite safety testing, transporter assessments, Phase 0 testing, and development and execution of drug interaction programs reflect current regulatory topics meant to address enhancement of both safety assessment and early decision-making during new candidate selection. Important technologies like whole body autoradiography, digital imaging and dried blood spot sample collection methods are introduced, as both have begun to take a more visible role in pharmacokinetic departments throughout the industry.
Drug Metabolism in Drug Design and Development
Language: en
Pages: 448
Authors: Donglu Zhang, Mingshe Zhu, William G. Humphreys
Categories: Science
Type: BOOK - Published: 2007-11-16 - Publisher: John Wiley & Sons
The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed by experts in their specific areas, this reference covers: * Basic concepts of drug metabolism * The role of drug metabolism in the pharmaceutical industry * Analytical techniques in drug metabolism * Common experimental approaches and protocols Drug Metabolism in Drug Design and Development emphasizes practical considerations such as the data needed, the experiments and analytical methods typically employed, and the interpretation and application of data. Chapters highlight facts, common protocols, detailed experimental designs, applications, and limitations of techniques. This is a comprehensive, hands-on reference for drug metabolism researchers as well as other professionals involved in pre-clinical drug discovery and development.
Optimal Dose Identification
Language: en
Pages: 278
Authors: Fundación Dr. Antonio Esteve. Symposium
Categories: Medical
Type: BOOK - Published: 2001 - Publisher: Elsevier
These proceedings provide a general update in an important area of clinical pharmacology; describing how individual subjects vary in their response to drugs and how this information can be used to optimise drug dosing in disease. These proceedings cover areas such as the relevance of studies at various stages of drug development, in optimising drug dosing, the role that pharmacokinetics and pharmacodynamics play and how molecular biology has an increasingly important role in this area. As examples of how these influences may play a role, consideration is given to how drug dosing is optimised in various diseases such as cancer, psychiatric and cardiovascular disease, as well as considering the role that age may play in predicting drug dose. The major theme of this volume is that choosing the optimal dose of a drug has never been more important as risk and benefits must be carefully assessed. There are a series of underlying principles which help determine the optimal dose, and these are dealt with in a systematic manner, using relevant disease states to illustrate these principles.
Applications of Pharmacokinetic Principles in Drug Development
Language: en
Pages: 550
Authors: Rajesh Krishna
Categories: Medical
Type: BOOK - Published: 2004 - Publisher: Springer Science & Business Media
This book presents a collection of articles that represent individual and expert perspectives in both preclinical and clinical development, including case studies on real-life examples of successful drugs that add value to the pharmacokinetic principles learned and applied. Unlike existing books that focus on pharmacokinetic theory, the current book emphasizes application of pharmacokinetic principles in new drug development.
Drug Discovery
Language: en
Pages: 570
Authors: Jie Jack Li, E. J. Corey
Categories: Medical
Type: BOOK - Published: 2013-04-12 - Publisher: John Wiley & Sons
Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design. Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contributions are based on a thorough review of the current literature as well as the authors' firsthand laboratory experience in drug discovery. The book begins with the history of drug discovery, describing groundbreaking moments in the field. Next, it covers such topics as: Target identification and validation Drug metabolism and pharmacokinetics Central nervous system drugs In vitro and in vivo assays Cardiovascular drugs Cancer drugs Each chapter features a case study, helping readers understand how science is put into practice throughout all phases of drug discovery. References at the end of each chapter serve as a gateway to
Xenobiotica
Language: en
Pages:
Authors: Jie Jack Li, E. J. Corey
Categories: Biochemistry
Type: BOOK - Published: 1992 - Publisher:
Books about Xenobiotica
Biochemistry, Biomolecules
Language: en
Pages: 1200
Authors: Donald Voet, Judith G. Voet
Categories: Science
Type: BOOK - Published: 2003-05-20 - Publisher: Wiley
Biochemistry is a modern classic that had been thoroughly revised. Explains biochemical concepts while offering a unified presentation of life and its variation through evolution. Incorporates both classical and current research to illustrate the historical source of much of our biochemical knowledge. This edition has been updated to reflect the enormous advances in molecular and protein structure. Features a new chapter on nucleic acids, gene expression, and recombinant DNA technology, as well as a new chapter on nucleotide metabolism. Integrated Biochemical Interactions CD.
Research Awards Index
Language: en
Pages:
Authors: Donald Voet, Judith G. Voet
Categories: Medicine
Type: BOOK - Published: 1979 - Publisher:
Books about Research Awards Index