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2 Oxoglutarate Dependent Oxygenases

Cj 2015 2
Author: Christopher J Schofield
Publisher: Royal Society of Chemistry
ISBN: 1849739501
Size: 22.56 MB
Format: PDF, ePub
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Since the discovery of the first examples of 2-oxoglutarate-dependent oxygenase-catalysed reactions in the 1960s, a remarkably broad diversity of alternate reactions and substrates has been revealed, and extensive advances have been achieved in our understanding of the structures and catalytic mechanisms. These enzymes are important agrochemical targets and are being pursued as therapeutic targets for a wide range of diseases including cancer and anemia. This book provides a central source of information that summarizes the key features of the essential group of 2-oxoglutarate-dependent dioxygenases and related enzymes. Given the numerous recent advances and biomedical interest in the field, this book aims to unite the latest research for those already working in the field as well as to provide an introduction for those newly approaching the topic, and for those interested in translating the basic science into medicinal and agricultural benefits. The book begins with four broad chapters that highlight critical aspects, including an overview of possible catalytic reactions, structures and mechanisms. The following seventeen chapters focus on carefully selected topics, each written by leading experts in the area. Readers will find explanations of rapidly evolving research, from the chemistry of isopenicillin N synthase to the oxidation mechanism of 5-methylcytosine in DNA by ten-eleven-translocase oxygenases.
2-Oxoglutarate-Dependent Oxygenases
Language: en
Pages: 487
Authors: Christopher J Schofield, Robert P Hausinger
Categories: Science
Type: BOOK - Published: 2015-05-06 - Publisher: Royal Society of Chemistry
Since the discovery of the first examples of 2-oxoglutarate-dependent oxygenase-catalysed reactions in the 1960s, a remarkably broad diversity of alternate reactions and substrates has been revealed, and extensive advances have been achieved in our understanding of the structures and catalytic mechanisms. These enzymes are important agrochemical targets and are being pursued as therapeutic targets for a wide range of diseases including cancer and anemia. This book provides a central source of information that summarizes the key features of the essential group of 2-oxoglutarate-dependent dioxygenases and related enzymes. Given the numerous recent advances and biomedical interest in the field, this book aims to unite the latest research for those already working in the field as well as to provide an introduction for those newly approaching the topic, and for those interested in translating the basic science into medicinal and agricultural benefits. The book begins with four broad chapters that highlight critical aspects, including an overview of possible catalytic reactions, structures and mechanisms. The following seventeen chapters focus on carefully selected topics, each written by leading experts in the area. Readers will find explanations of rapidly evolving research, from the chemistry of isopenicillin N synthase to the oxidation mechanism of 5-methylcytosine in
Guidelines for the Treatment of Malaria. Third Edition
Language: en
Pages: 313
Authors: World Health Organization
Categories: Medical
Type: BOOK - Published: 2015-08-13 - Publisher: World Health Organization
Malaria remains an important cause of illness and death in children and adults in countries in which it is endemic. Malaria control requires an integrated approach including prevention (primarily vector control) and prompt treatment with effective antimalarial agents. Malaria case management consisting of prompt diagnosis and effective treatment remains a vital component of malaria control and elimination strategies. Since the publication of the first edition of the Guidelines for the treatment of malaria in 2006 and the second edition in 2010 all countries in which P. falciparum malaria is endemic have progressively updated their treatment policy from use of ineffective monotherapy to the currently recommended artemisinin-based combination therapies (ACT). This has contributed substantially to current reductions in global morbidity and mortality from malaria. Unfortunately resistance to artemisinins has arisen recently in P. falciparum in South-East Asia which threatens these gains. This third edition of the WHO Guidelines for the treatment of malaria contains updated recommendations based on a firmer evidence base for most antimalarial drugs and in addition include recommendation on the use of drugs to prevent malaria in groups at high risk. The Guidelines provide a framework for designing specific detailed national treatment protocols taking into account local patterns
Parenting Matters
Language: en
Pages: 524
Authors: National Academies of Sciences, Engineering, and Medicine, Division of Behavioral and Social Sciences and Education, Board on Children, Youth, and Families, Committee on Supporting the Parents of Young Children
Categories: Social Science
Type: BOOK - Published: 2016-12-21 - Publisher: National Academies Press
Decades of research have demonstrated that the parent-child dyad and the environment of the familyâ€"which includes all primary caregiversâ€"are at the foundation of children's well- being and healthy development. From birth, children are learning and rely on parents and the other caregivers in their lives to protect and care for them. The impact of parents may never be greater than during the earliest years of life, when a child's brain is rapidly developing and when nearly all of her or his experiences are created and shaped by parents and the family environment. Parents help children build and refine their knowledge and skills, charting a trajectory for their health and well-being during childhood and beyond. The experience of parenting also impacts parents themselves. For instance, parenting can enrich and give focus to parents' lives; generate stress or calm; and create any number of emotions, including feelings of happiness, sadness, fulfillment, and anger. Parenting of young children today takes place in the context of significant ongoing developments. These include: a rapidly growing body of science on early childhood, increases in funding for programs and services for families, changing demographics of the U.S. population, and greater diversity of family structure. Additionally, parenting is
Improving Diagnosis in Health Care
Language: en
Pages: 472
Authors: National Academies of Sciences, Engineering, and Medicine, Institute of Medicine, Board on Health Care Services, Committee on Diagnostic Error in Health Care
Categories: Medical
Type: BOOK - Published: 2016-01-29 - Publisher: National Academies Press
Getting the right diagnosis is a key aspect of health care - it provides an explanation of a patient's health problem and informs subsequent health care decisions. The diagnostic process is a complex, collaborative activity that involves clinical reasoning and information gathering to determine a patient's health problem. According to Improving Diagnosis in Health Care, diagnostic errors-inaccurate or delayed diagnoses-persist throughout all settings of care and continue to harm an unacceptable number of patients. It is likely that most people will experience at least one diagnostic error in their lifetime, sometimes with devastating consequences. Diagnostic errors may cause harm to patients by preventing or delaying appropriate treatment, providing unnecessary or harmful treatment, or resulting in psychological or financial repercussions. The committee concluded that improving the diagnostic process is not only possible, but also represents a moral, professional, and public health imperative. Improving Diagnosis in Health Care a continuation of the landmark Institute of Medicine reports To Err Is Human (2000) and Crossing the Quality Chasm (2001) finds that diagnosis-and, in particular, the occurrence of diagnostic errorsâ€"has been largely unappreciated in efforts to improve the quality and safety of health care. Without a dedicated focus on improving diagnosis, diagnostic errors will
An Introduction to Efficiency and Productivity Analysis
Language: en
Pages: 349
Authors: Timothy J. Coelli, Dodla Sai Prasada Rao, Christopher J. O'Donnell, George Edward Battese
Categories: Business & Economics
Type: BOOK - Published: 2005-07-22 - Publisher: Springer Science & Business Media
Softcover version of the second edition Hardcover. Incorporates a new author, Dr. Chris O'Donnell, who brings considerable expertise to the project in the area of performance measurement. Numerous topics are being added and more applications using real data, as well as exercises at the end of the chapters. Data sets, computer codes and software will be available for download from the web to accompany the volume.
Medicinal Chemistry of Anticancer Drugs
Language: en
Pages: 768
Authors: Carmen Avendano, J. Carlos Menendez
Categories: Medical
Type: BOOK - Published: 2015 - Publisher: Elsevier Science
Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature
Treatise on Titrimetry: Inorganic titrimetric analysis, by W. Wagner and C. J. Hull
Language: en
Pages:
Authors: Joseph Jordan
Categories: Volumetric analysis
Type: BOOK - Published: 1971 - Publisher:
Books about Treatise on Titrimetry: Inorganic titrimetric analysis, by W. Wagner and C. J. Hull
Polish Botanical Studies
Language: en
Pages:
Authors: Joseph Jordan
Categories: Botany
Type: BOOK - Published: 1993 - Publisher:
Books about Polish Botanical Studies
The American Aberdeen-Angus Herd-book
Language: en
Pages:
Authors: American Aberdeen-Angus Breeders' Association
Categories: Aberdeen-Angus cattle
Type: BOOK - Published: 1961 - Publisher:
Books about The American Aberdeen-Angus Herd-book
Reproductive, Maternal, Newborn, and Child Health
Language: en
Pages: 416
Authors: Robert E. Black, Marleen Temmerman, Neff Walker, Ramanan Laxminarayan
Categories: Medical
Type: BOOK - Published: 2016-05-25 - Publisher: World Bank
Reproductive, maternal, newborn, and child health : an overview / Robert Black, Marleen Temmerman, and Neff Walker -- The burden of reproductive ill health / Alex Ezeh, Abdhalah K. Ziraba, John Cleland, Akinrinota Bankole, anmd Claudia Garcia Moreno Esteva -- Levels and causes of maternal mortality and morbidity / Veronique Filippi, Doris Chou, Carine Ronsmans, Wendy Graham, and Lale Say -- Levels and causes of mortality under age five years / Li Liu, Kenneth Hill, Shefali Oza, Dan Hogan, Simon Cousens, Colin Mathers, Cynthia Stanton, Joy Lawn, Robert E. Black -- Levels and trends in low height-for-age / Gretchen Stevens, Mariel Finucane, and Christopher Paciorek -- Interventions to improve reproductive health / John Stover, Karen Hardee, Bella Ganatra, Claudia García Moreno, and Susan E. Horton -- Interventions to reduce maternal and newborn morbidity and mortality / A. Metin Gülmezoglu, Theresa A. Lawrie, Natasha Hezelgrave, Olufemi T. Oladapo, João Paulo Souza, Marijke Gielen, Joy E. Lawn, Rajiv Bahl, Fernando Althabe, Daniela Colaci, and G. Justus Hofmey -- Diagnosis and treatment of the febrile child / Julie M. Herlihy, Valérie DʼAcremont, Deborah C. Hay Burgess, and Davidson H. Hamer -- Diarrheal diseases / Gerald T. Keusch, Christa Fischer-Walker, Jai K. Das, Susan